dc.contributor.author | Torumkuney, D. | |
dc.contributor.author | Gur, D. | |
dc.contributor.author | Soyletir, G. | |
dc.contributor.author | Gurler, N. | |
dc.contributor.author | Aktas, Z. | |
dc.contributor.author | Sener, B. | |
dc.contributor.author | Tunger, A. | |
dc.contributor.author | Bayramoglu, G. | |
dc.contributor.author | Koksal, I. | |
dc.contributor.author | Yalcin, A. N. | |
dc.contributor.author | Tanriver, Y. | |
dc.contributor.author | Morrissey, I. | |
dc.contributor.author | Barker, K. | |
dc.date.accessioned | 2020-02-17T08:12:22Z | |
dc.date.available | 2020-02-17T08:12:22Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0305-7453 | |
dc.identifier.uri | https://doi.org/10.1093/jac/dkw067 | |
dc.identifier.uri | http://hdl.handle.net/11655/22113 | |
dc.description.abstract | Objectives: To investigate changes in antibiotic susceptibility of Streptococcus pneumoniae and Haemophilus influenzae from the Survey of Antibiotic Resistance (SOAR) in community-acquired respiratory tract infections (CA-RTIs) between 2002 and 2009 in Turkey. Methods: Previously published SOAR data were used for this analysis. MICs were determined using Etest (R) gradient strips or disc diffusion. Susceptibility against a range of antimicrobial agents was assessed using CLSI breakpoints. Results: A total of 900 S. pneumoniae isolates were analysed: 2002-03 (n = 75), 2004-05 (n = 301) and 2007-09 (n = 524). Four antibiotics were tested consistently throughout and three showed a statistically significant decrease in susceptibility (P < 0.0001): penicillin (74.7% susceptible in 2002-03; 67.8% in 2004-05; and 47.2% in 2007-09); cefaclor (85.3% in 2002-03; 78.7% in 2004-05; and 53.5% in 2007-09) and clarithromycin (85.3% in 2002-03; 82.7% in 2004-05; and 61.9% in 2007-09). Susceptibility to amoxicillin/clavulanic acid did not significantly change (100% in 2002-03; 98.7% in 2004-05; and 97.7% in 2007-09). A total of 930 H. influenzae isolates were analysed: 2002-03 (n = 133), 2004-05 (n = 379) and 2007-09 (n = 418). Four anti-biotics were also consistently tested: ampicillin, amoxicillin/clavulanic acid, clarithromycin and cefaclor. All showed >90% susceptibility, but only cefaclor susceptibility significantly reduced (P<0.0001) over time (99.2% in 2002-03; 96.3% in 2004-05; and 90.4% in 2007-09). Conclusions: In S. pneumoniae from Turkey, there has been a clear statistically significant reduction in susceptibility to key antibiotics since 2002, but not to amoxicillin/clavulanic acid (or amoxicillin). However, susceptibility in H. influenzae remained stable. Continued surveillance is required to monitor future changes in antibiotic susceptibility for CA-RTI bacteria. | tr_TR |
dc.language.iso | en | tr_TR |
dc.publisher | Oxford Univ Press | tr_TR |
dc.relation.isversionof | 10.1093/jac/dkw067 | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | tr_TR |
dc.subject | Antibiotic resistance | tr_TR |
dc.subject | Streptococcus pneumoniae | tr_TR |
dc.subject | Haemophilus influenzae | tr_TR |
dc.subject | Turkey | tr_TR |
dc.subject.lcsh | Tıp | tr_TR |
dc.title | Results From The Survey of Antibiotic Resistance (SOAR) 2002-09 in Turkey | tr_TR |
dc.type | info:eu-repo/semantics/article | tr_TR |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Journal Of Antimicrobial Chemotherapy | tr_TR |
dc.contributor.department | Tıbbi Mikrobiyoloji | tr_TR |
dc.identifier.volume | 71 | tr_TR |
dc.identifier.startpage | 85 | tr_TR |
dc.identifier.endpage | 91 | tr_TR |
dc.description.index | WoS | tr_TR |
dc.description.index | Scopus | tr_TR |
dc.funding | Yok | tr_TR |