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dc.contributor.authorErgin, Alper
dc.contributor.authorErcis, Serpil
dc.contributor.authorHasçelik, Gülşen
dc.date.accessioned2020-01-28T10:45:16Z
dc.date.available2020-01-28T10:45:16Z
dc.date.issued2006
dc.identifier.urihttps://doi.org/10.1093/jac/dki404
dc.identifier.urihttps://www.scopus.com/inward/record.url?eid=2-s2.0-30344437587&partnerID=40&md5=b4ece1b5c67e158e4e1e45ea879e6fd0
dc.identifier.urihttp://hdl.handle.net/11655/21895
dc.description.abstractObjectives: Our aim was to study the macrolide resistance mechanisms and antimicrobial susceptibilities of viridans group streptococci (VGS) isolated from blood cultures. Methods: In vitro susceptibilities to nine antimicrobials were studied for 85 VGS isolated from blood cultures by agar dilution. Pheno- and genotyping of erythromycin-resistant isolates were studied by the double disc test and PCR. Results: Resistance to erythromycin was found in 27% (n = 23) of the isolates. Erythromycin-resistant Streptococcus oralis (n = 13) predominated among the other erythromycin-resistant species isolated. The phenotypes among 23 erythromycin-resistant isolates were as follows: 12 constitutive macrolide– lincosamide–streptogramin (cMLSB) resistance phenotype and 11 macrolide (M) resistance phenotype. Of the cMLSB isolates 11 had erm(B) genes and 11 of the M phenotype isolates had mef(A) genes. Four of the cMLSB isolates had both erm(B) and mef(A) genes. None of the isolates had erm(TR) genes. Combined resistance to erythromycin with penicillin, clindamycin, chloramphenicol, tetracycline and quinupristin/dalfopristin was found in 100, 61, 74, 100 and 100% of the isolates, respectively. No resistance was found for vancomycin, linezolid and levofloxacin. Conclusions: The macrolide resistance mechanisms of our VGS isolates revealed that the cMLSB phenotype associated with erm(B) and the M phenotype associated with mef(A) genes are found with similar frequencies.tr_TR
dc.language.isoentr_TR
dc.publisherOxford Univ Presstr_TR
dc.relation.isversionof10.1093/jac/dki404tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectErythromycin resistancetr_TR
dc.subjectM phenotypetr_TR
dc.subjectS. oralistr_TR
dc.subjectErm(B)tr_TR
dc.subjectMef(A)tr_TR
dc.subject.lcshMakrolid Antibiyotiklertr_TR
dc.titleMacrolide Resistance Mechanisms and in Vitro Susceptibility Patterns of Viridans Group Streptococci Isolated from Blood Culturestr_TR
dc.typeinfo:eu-repo/semantics/articletr_TR
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalJournal of Antimicrobial Chemotherapytr_TR
dc.contributor.departmentTıbbi Laboratuvar Teknikleritr_TR
dc.identifier.volume57tr_TR
dc.identifier.issue1tr_TR
dc.identifier.startpage139tr_TR
dc.identifier.endpage141tr_TR
dc.description.indexScopustr_TR
dc.fundingYoktr_TR


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