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Antigen Recognition and The Immune Response: Structural Requirements in The Side Chain Of Tyrosine For Immunogenicity of L-Tyrosine-Azobenzenearsonate

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Date
1972
Author
Alkan, S.S.
Bush, M.E.
Nitecki, D.E.
Goodman, J.W.
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Abstract
The low molecular weight compound L-tyrosine-azobenzenearsonate (RAT) induces a cellular immune response in guinea pigs. The contribution of the side chain of tyrosine to the immunogenicity of RAT and the structural requirements at that position for immunogenicity were assessed by synthesizing a series of analogs of RAT containing modifications in the side chain of tyrosine and employing them as immunogens. Removal of either the carboxyl or amino group did not markedly affect immunogenicity, measured by the induction of delayed cutaneous sensitivity, whereas deletion of both completely abolished it. However, a charged group was not required since side chains containing a polar hydroxyl group could substitute for chains bearing an amino or carboxyl group. The size of the side chain exerted a pronounced influence; the charged or polar substituent had to be extended from the phenolic ring by at least two carbon atoms in order to confer immunogenicity.
URI
https://doi.org/10.1084/jem.136.2.387
https://www.scopus.com/inward/record.url?eid=2-s2.0-0015382868&partnerID=40&md5=eee8c96bc7e23cf90d88c9df4bf4a147
http://hdl.handle.net/11655/21854
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  • Temel Tıp Bilimleri Bölümü Makale Koleksiyonu [459]
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