Heparin Removal from Human Blood with Heparin Imprinted Polymeric Cryogels

Abstract

Heparin is an effective antithrombotic agent that reduces morbidity and mortality among patients having deep vein thrombosis and pulmonary embolism. Patients are administered heparin to minimize the risks associated with surgical procedures. Excessive heparinization has been shown to increase the frequency of thrombosis, which may lead to serious haemorrhagic complication. Such a high risk can be especially dangerous for patients with previously silent lesions (e.g. carcinoma, gastrointestinal ulcers, and trauma) that may be revealed for the first time during heparin therapy. The physician must adjust the dosage of anticoagulant for these patients, to maintain sufficient level to prevent thrombosis and to avoid bleeding.