Filagrin Polimorfizmlerinin Besin Alerjisi ve Atopik Dermatit Ile İlişkisinin Araştırılması

Abstract

Filaggrin (FLG), involved in the formation of skin barrier and be assigned in epidermal differentiation is a protein complex. Studies have shown that changes of FLG gene associated with allergen sensitivity and allergic diseases which are ichthyosis vulgaris, allergic rhinitis, atopic dermatitis (AD), food allergy and asthma.Atopic diseases are related to each other in a process. Process representing natural course of atopic evidence is called as an atopic march . In the atopic march, first encountered atopic allergic disease is generally atopic dermatitis, and then the clinical signs of food allergy occur. Atopic dermatitis is considered to be the origin of the allergic process. Sensitivity of airway allergen is developed in the later years of life and allergic rhinitis and asthma are added to disease table.