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dc.contributor.authorAgar, Osman Tuncay
dc.contributor.authorDikmen, Miris
dc.contributor.authorOzturk, Nilgun
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.contributor.authorTemel, Hamdi
dc.contributor.authorTurkmenoglu, Fatma Pinar
dc.date.accessioned2019-12-16T10:09:44Z
dc.date.available2019-12-16T10:09:44Z
dc.date.issued2015
dc.identifier.issn1420-3049
dc.identifier.urihttps://doi.org/10.3390/molecules201017976
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332372/
dc.identifier.urihttp://hdl.handle.net/11655/19957
dc.description.abstractTurkey is one of the most important centers of diversity for the genus Achillea L. in the world. Keeping in mind the immense medicinal importance of phenols, in this study, three species growing in Turkey, A. coarctata Poir. (AC), A. kotschyi Boiss. subsp. kotschyi (AK) and A. lycaonica Boiss. & Heldr. (AL) were evaluated for their phenolic compositions, total phenolic contents (TPC), antioxidant properties, wound healing potencies on NIH-3T3 fibroblasts and cytotoxic effects on MCF-7 human breast cancer cells. Comprehensive LC-MS/MS analysis revealed that AK was distinctively rich in chlorogenic acid, hyperoside, apigenin, hesperidin, rutin, kaempferol and luteolin (2890.6, 987.3, 797.0, 422.5, 188.1, 159.4 and 121.2 µg analyte/g extract, respectively). The findings exhibited a strong correlation between TPC and both free radical scavenging activity and total antioxidant capacity (TAC). Among studied species, the highest TPC (148.00 mg GAE/g extract) and TAC (2.080 UAE), the strongest radical scavenging (EC50 = 32.63 μg/mL), the most prominent wound healing and most abundant cytotoxic activities were observed with AK. The results suggested that AK is a valuable source of flavonoids and chlorogenic acid with important antioxidant, wound healing and cytotoxic activities. These findings warrant further studies to assess the potential of AK as a bioactive source that could be exploited in pharmaceutical, cosmetics and food industries.
dc.relation.isversionof10.3390/molecules201017976
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleComparative Studies On Phenolic Composition, Antioxidant, Wound Healing And Cytotoxic Activities Of Selected Achillea L. Species Growing In Turkey
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalMolecules
dc.contributor.departmentFarmasötik Botanik
dc.identifier.volume20
dc.identifier.issue10
dc.identifier.startpage17976
dc.identifier.endpage18000
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus


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