dc.contributor.author | Bakhshpour, Monireh | |
dc.contributor.author | Yavuz, Handan | |
dc.contributor.author | Denizli, Adil | |
dc.date.accessioned | 2019-12-16T09:18:44Z | |
dc.date.available | 2019-12-16T09:18:44Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2169-1401 | |
dc.identifier.uri | https://doi.org/10.1080/21691401.2018.1439840 | |
dc.identifier.uri | http://hdl.handle.net/11655/19609 | |
dc.description.abstract | Molecular imprinting technique was used for the preparation of antibiotic and anti-neoplastic chemotherapy drug (mitomycin C) imprinted cryogel membranes (MMC-ICM). The membranes were synthezied by using metal ion coordination interactions with N-methacryloyl-(l)-histidine methyl ester (MAH) functional monomer and template molecules (i.e. MMC). The 2-hydroxyethyl methacrylate (HEMA) monomer and methylene bisacrylamide (MBAAm) crosslinker were used for the preparation of mitomycin C imprinted cryogel membranes by radical suspension polymerization technique. The imprinted cryogel membranes were characterized by scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET), Fourier transform infrared spectroscopy-attenuated total reflectance (FTIR-ATR) and swelling degree measurements. Cytotoxicity of MMC-ICMs was investigated using mouse fibroblast cell line L929. Time-dependent release of MMC was demonstrated within 150h from cryogel membranes. Cryogels demonstrated very high MMC loading efficiency (70-80%) and sustained MMC release over hours. | |
dc.language.iso | en | |
dc.publisher | Taylor & Francis Ltd | |
dc.relation.isversionof | 10.1080/21691401.2018.1439840 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Biotechnology & Applied Microbiology | |
dc.subject | Engineering | |
dc.subject | Materials Science | |
dc.title | Controlled Release Of Mitomycin C From Phemah-Cu(Ii) Cryogel Membranes | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Artificial Cells Nanomedicine And Biotechnology | |
dc.contributor.department | Kimya | |
dc.identifier.volume | 46 | |
dc.identifier.startpage | S946 | |
dc.identifier.endpage | S954 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |