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dc.contributor.authorDurakoglugil, Murat S.
dc.contributor.authorOrer, Hakan S.
dc.date.accessioned2019-12-16T09:18:40Z
dc.date.available2019-12-16T09:18:40Z
dc.date.issued2008
dc.identifier.issn1550-9702
dc.identifier.urihttps://doi.org/
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614708/
dc.identifier.urihttp://hdl.handle.net/11655/19604
dc.description.abstractThe effects of cannabinoids on the baroreflex have been investigated in the nucleus tractus solitarii (NTS). In urethane-anesthetized rats, microinjection of the cannabinoid (CB) receptor agonist WIN 55212-2 (100 mM) into the NTS produced a short lasting decrease in arterial pressure (from 95.2 ± 2.9 to 76.2 ± 1.5, n=5, P<0.05) but no change in the heart rate. Another cannabinoid agonist, CP 55940 (100 mM) also caused hypotensive responses (from 90.2 ± 11.3 to 66.4 ± 12.3 mmHg, n=5, P<0.05). Simultaneous sympathetic nerve discharge recordings showed suppression prior to the arterial pressure lowering effect of these agonists. Microinjection of the cannabinoid receptor antagonist, AM 281 (70 mM) did not cause any significant change in arterial pressure (from 100.8 ± 12 mmHg to 108.1 ± 12.8 mmHg, n=5, P>0.05) though it inhibited the agonist-induced responses. The non-NMDA receptor antagonist, DNQX (4 mM) microinjections antagonized the actions of CB agonist WIN 55212-2. Furthermore, sinoaortic denervation attenuated the responses to CB agonists suggesting an intact baroreflex arc is necessary to elicit CB-mediated effects. Neither WIN 55212-2 nor AM 281, altered baroreceptor reflex activation by bolus phenylephrine (25 microg//kg) injections. These data suggest that cannabinoid receptors in the NTS are not involved in the tonic regulation of the arterial pressure but may have a modulatory role in the baroreceptor reflex integration.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleCannabinoid Receptor Activation In The Nucleus Tractus Solitaries Produces Baroreflex-Like Responses In The Rat
dc.typeinfo:eu-repo/semantics/article
dc.relation.journalInternational Journal of Biomedical Science : IJBS
dc.contributor.departmentKimya
dc.identifier.volume4
dc.identifier.issue3
dc.identifier.startpage229
dc.identifier.endpage237
dc.description.indexPubMed


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