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Antibacterial Chitosan/Silk Sericin 3D Porous Scaffolds As A Wound Dressing Material

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Antibacterial chitosan silk sericin 3D porous scaffolds as a wound dressing material.pdf (5.908Mb)
Date
2017
Author
Karahaliloğlu, Zeynep
Kılıcay, Ebru
Denkbas, Emir Baki
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Abstract
Antimicrobial mixed dressings have traditionally been used to minimize bacterial infection of burns and other wounds. This study presents the advancement of biocompatible chitosan/silk sericin (CHT/SS) scaffolds combined with lauric acid (LA) and zinc oxide nanoparticles (nZnO) for the successful wound dressing applications. Antibacterial assay results showed that the diameters of the inhibition zone increased from 2 +/- 0.4 to 7 +/- 0.1mm for Escherichia coli, as well as from 2.5 +/- 0.2 to 6 +/- 0.4mm for Staphylococcus aureus while CHTS/SS/100nZnO compared to CHT/SS/0.01LA. The results not only showed excellent inhibition against Gram-positive and Gram-negative bacterial growth but also revealed improved proliferation and extended viability for HaCaT cells.
URI
https://doi.org/10.1080/21691401.2016.1203796
http://hdl.handle.net/11655/19600
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