Show simple item record

dc.contributor.authorMergen, Hatice
dc.contributor.authorKaraaslan, Cagatay
dc.contributor.authorMergen, Mehmet
dc.contributor.authorOezsoy, Ergi Deniz
dc.contributor.authorOezata, Metin
dc.date.accessioned2019-12-16T07:56:50Z
dc.date.available2019-12-16T07:56:50Z
dc.date.issued2007
dc.identifier.issn0918-8959
dc.identifier.urihttps://doi.org/10.1507/endocrj.K06-023
dc.identifier.urihttp://hdl.handle.net/11655/19302
dc.description.abstractObesity is a growing problem and is associated with numerous medical conditions. In several genes coding for molecules involved in the regulation of body weight (fat mass) and thermogenesis, polymorphisms have been reported which possibly modify human obesity risk. The aim of this study was to determine the incidence of the following polymorphisms in the following genes in 262 obese (BMI :30) and 138 control (BMI: 25) subjects: leptin receptor (LEPR)-Gln223Arg, B-3-adrenergic receptor (B-3-AR)-Trp64Arg, serotonin transporter (5-HTT)-a 44-base pair insertion/ deletion functional polymorphism in the 5-HTTLPR and insulin receptor substrate-1 (IRS-1)-Gly972Arg. Our hypothesis was that these polymorphisms would occur more frequently in the obese population. The polymorphisms were determined by polymerase chain reaction (PCR) and restriction genotyping in study population. In our results, no strong associations were observed between BMI status and these polymorphisms. Weak, though significant, association coefficients obtained with HTT and LEPR loci indicate that the genotype numbers at these loci may depend on BM I status to some extent.
dc.language.isoen
dc.publisherJapan Endocrine Society
dc.relation.isversionof10.1507/endocrj.K06-023
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEndocrinology & Metabolism
dc.titleLepr, Adbr3, Irs-1 And 5-Htt Genes Polymorphisms Do Not Associate with Obesity
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalEndocrine Journal
dc.contributor.departmentBiyoloji
dc.identifier.volume54
dc.identifier.issue1
dc.identifier.startpage89
dc.identifier.endpage94
dc.description.indexWoS
dc.description.indexScopus


Files in this item

This item appears in the following Collection(s)

Show simple item record