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dc.contributor.authorTopcuoglu, Pelin Traje
dc.contributor.authorUzun, Sennur
dc.contributor.authorCanbay, Ozgur
dc.contributor.authorPamuk, Gulsun
dc.contributor.authorOzgen, Saadet
dc.date.accessioned2019-12-12T06:42:41Z
dc.date.available2019-12-12T06:42:41Z
dc.date.issued2010
dc.identifier.issn0832-610X
dc.identifier.urihttps://doi.org/10.1007/s12630-009-9217-4
dc.identifier.urihttp://hdl.handle.net/11655/16749
dc.description.abstractBoth ketamine and priming may shorten the onset time of rocuronium. This study investigates the effects of ketamine and priming as components of a propofol induction on intubating conditions and onset of neuromuscular block. This prospective randomized double-blind study was performed in 120 American Society of Anesthesiologists (ASA) I-II patients who were assigned to one of four groups of 30 patients each: control, priming, ketamine, and ketamine-priming. Ketamine 0.5 mg a (TM) kg(-1) or saline was given before priming and induction. Rocuronium 0.06 mg a (TM) kg(-1) or saline was injected 2 min before propofol 2.5 mg a (TM) kg(-1). This was followed by rocuronium 0.6 mg a (TM) kg(-1) or by rocuronium 0.54 mg a (TM) kg(-1) if priming was given. Intubation was performed one minute later. Intubating conditions were graded as excellent, good, or poor. Heart rate, noninvasive blood pressure, and train-of-four (TOF) response were monitored. Intubating conditions were graded excellent in 20% of the control group, 30% of the priming group, 47% of the ketamine group, and 57% of the ketamine-priming group. Analysis using forward stepwise regression indicated that ketamine improved intubating conditions (P = 0.001) but priming did not (P = 0.35). Time to reach a TOF count of zero was shortened by ketamine (P = 0.001) but not by priming (P = 0.94): 216 +/- A 20 s in the control group, 212 +/- A 27 s in the priming group, 162 +/- A 18 s in the ketamine group, and 168 +/- A 22 s in the ketamine-priming group. A low-dose ketamine used with a propofol-rocuronium induction improved intubating conditions and shortened onset time. Priming did not influence intubating conditions or onset time.
dc.language.isoen
dc.publisherSpringer
dc.relation.isversionof10.1007/s12630-009-9217-4
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnesthesiology
dc.titleKetamine, but not Priming, Improves Intubating Conditions During a Propofol-Rocuronium Induction
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalCanadian Journal Of Anaesthesia-Journal Canadien D Anesthesie
dc.contributor.departmentAnesteziyoloji ve Reanimasyon
dc.identifier.volume57
dc.identifier.issue2
dc.identifier.startpage113
dc.identifier.endpage119
dc.description.indexWoS
dc.description.indexScopus


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