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dc.contributor.authorDemir, Ersin
dc.contributor.authorInam, Onur
dc.contributor.authorInam, Recai
dc.date.accessioned2019-12-12T06:40:31Z
dc.date.available2019-12-12T06:40:31Z
dc.date.issued2018
dc.identifier.issn0910-6340
dc.identifier.urihttps://doi.org/10.2116/analsci.17P589
dc.identifier.urihttp://hdl.handle.net/11655/16567
dc.description.abstractProparacaine, one of the most common local anesthetics to facilitate diagnosis and treatment of eye diseases, was assayed by square wave voltammetry using a paste electrode prepared with carbon nanotubes. In cyclic voltammetric studies, proparacaine has exhibited a single irreversible anodic peak at around + 900 mV vs. Ag/AgCl in pH 6.0 Britton-Robinson buffer solution. It was suggested that the peak had appeared due to the oxidation of the NH2 group on the proparacaine molecule. Prior to the determination of the proparacaine by square wave stripping voltammetry (SWSV) on the fabricated multi-walled carbon nanotube paste electrode (MWCNTPE), the accumulation potential (E-acc), accumulation time (r.c), pulse amplitude (Delta E), step potential (Delta E-s) and frequency (f) parameters were optimized. The peak currents plotted in the range of 0.5 - 12.5 mg/L proparacaine exhibited two linear sections with a detection limit of 0.11 mg/L. The results for the determination of proparacaine on a pharmaceutical local anesthetic (Alcaine) showed that relative standard deviation (RSD) and relative error (RE) were 4.1 and 2.0%, respectively. Selectivity has also been investigated and results showed recoveries of 5.0 mg/L proparacaine in the presence of 5.0 mg/L dopamine, ascorbic acid and uric acid as 106.9 +/- 0.8, 99.9 +/- 1.2 and 94.1 +/- 0.7, respectively.
dc.language.isoen
dc.publisherJapan Soc Analytical Chemistry
dc.relation.isversionof10.2116/analsci.17P589
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChemistry
dc.titleDetermination Of Ophthalmic Drug Proparacaine Using Multi-Walled Carbon Nanotube Paste Electrode By Square Wave Stripping Voltammetry
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalAnalytical Sciences
dc.contributor.departmentGöz Hastalıkları
dc.identifier.volume34
dc.identifier.issue7
dc.identifier.startpage771
dc.identifier.endpage776
dc.description.indexWoS
dc.description.indexScopus


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