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dc.contributor.authorYeo, SF
dc.contributor.authorAkalin, E
dc.contributor.authorArikan, S
dc.contributor.authorAuckenthaler, R
dc.contributor.authorBergan, T
dc.contributor.authorDornbusch, K
dc.contributor.authorHoward, AJ
dc.contributor.authorHryniewicz, W
dc.contributor.authorJones, RN
dc.contributor.authorKoupari, G
dc.contributor.authorLegakis, NJ
dc.contributor.authorMcLaughlin, J
dc.contributor.authorOzkuyumcu, C
dc.contributor.authorPercival, A
dc.contributor.authorPhillips, I
dc.contributor.authorReeves, D
dc.contributor.authorSpencer, R
dc.contributor.authorWarren, RE
dc.contributor.authorWilliams, JD
dc.date.accessioned2019-12-12T06:26:05Z
dc.date.available2019-12-12T06:26:05Z
dc.date.issued1996
dc.identifier.issn0305-7453
dc.identifier.urihttps://doi.org/10.1093/jac/38.3.363
dc.identifier.urihttp://hdl.handle.net/11655/16350
dc.description.abstractIn order to compare the prevalence of antibiotic resistance in different geographical areas, it is necessary to ensure that agreement is achieved between laboratories on the assignment of strains to 'susceptible' and 'resistant' categories. An international quality assessment study, involving 15 laboratories in eight countries, was performed to investigate the standard of performance of the susceptibility testing of Haemophilus influenzae. One hundred and fifty strains of H. influenzae were distributed from the London Hospital Medical College (LHMC) to all laboratories who were asked to test the susceptibility of the strains to ampicillin, chloramphenicol, tetracycline, trimethoprim, cephalosporins and ciprofloxacin. Laboratories were also asked to provide the details of methodology to test the susceptibility. Significant discrepancy between the LHMC and the participating laboratories appeared in the detection of resistance to ampicillin (especially beta-lactamase-negative strains resistant to ampicillin) as well as the assignment of susceptibility and resistance to chloramphenicol, tetracycline and trimethoprim. Often these reflected the use of inappropriate breakpoints which led to erroneous assignment of susceptibility. Other variations including disc content, medium and supplement, inoculum as well as failure to measure zone sizes properly also led to some repeating anomalies.
dc.language.isoen
dc.publisherW B Saunders Co Ltd
dc.relation.isversionof10.1093/jac/38.3.363
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInfectious Diseases
dc.subjectMicrobiology
dc.subjectPharmacology & Pharmacy
dc.titleSusceptibility Testing of Haemophilus Influenzae - An International Collaborative Study in Quality Assessment
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalJournal Of Antimicrobial Chemotherapy
dc.contributor.departmentTıbbi Mikrobiyoloji
dc.identifier.volume38
dc.identifier.issue3
dc.identifier.startpage363
dc.identifier.endpage386
dc.description.indexWoS
dc.description.indexScopus


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