dc.contributor.author | Coban, Ahmet Yilmaz | |
dc.contributor.author | Akbal, Ahmet Ugur | |
dc.contributor.author | Bicmen, Can | |
dc.contributor.author | Albay, Ali | |
dc.contributor.author | Sig, Ali Korhan | |
dc.contributor.author | Uzun, Meltem | |
dc.contributor.author | Selale, Deniz Sertel | |
dc.contributor.author | Ozkutuk, Nuri | |
dc.contributor.author | Surucuoglu, Suheyla | |
dc.contributor.author | Albayrak, Nurhan | |
dc.contributor.author | Ucarman, Nilay | |
dc.contributor.author | Ozkutuk, Aydan | |
dc.contributor.author | Esen, Nuran | |
dc.contributor.author | Ceyhan, Ismail | |
dc.contributor.author | Ozyurt, Mustafa | |
dc.contributor.author | Bektore, Bayhan | |
dc.contributor.author | Aslan, Gonul | |
dc.contributor.author | Delialioglu, Nuran | |
dc.contributor.author | Alp, Alpaslan | |
dc.date.accessioned | 2019-12-12T06:25:27Z | |
dc.date.available | 2019-12-12T06:25:27Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://doi.org/10.1038/srep39050 | |
dc.identifier.uri | http://hdl.handle.net/11655/16288 | |
dc.description.abstract | The aim of this multicenter study was to evaluate the performance of the crystal violet decolorization assay (CVDA) for detection of multidrug resistant tuberculosis (MDR-TB). This study was performed in 11 centers in two phases. A total of 156 isolates were tested for INH and RIF resistance. In the phase I, 106 clinical isolates were tested in the Center 1-7. In the phase 2, 156 clinical isolates were tested in the center 1-6, center 8-11. Eighty six of 156 tested isolates were the same in phase I. Agreements were 96.2-96.8% for INH and 98.1-98.7% for RIF in the phase I-II, respectively. Mean time to obtain the results in the phase I was 14.3 +/- 5.4 days. In the phase II, mean time to obtain the results was 11.6 +/- 3.5 days. Test results were obtained within 14days for 62.3% (66/106) of isolates in the phase I and 81.4% (127/156) of isolates in the phase II. In conclusion, CVDA is rapid, reliable, inexpensive, and easy to perform for rapid detection of MDR-TB isolates. In addition, it could be adapted for drug susceptibility testing with all drugs both in developed and developing countries. | |
dc.language.iso | en | |
dc.publisher | Nature Publishing Group | |
dc.relation.isversionof | 10.1038/srep39050 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Science & Technology - Other Topics | |
dc.title | Multicenter Evaluation Of Crystal Violet Decolorization Assay (Cvda) For Rapid Detection Of Isoniazid And Rifampicin Resistance In Mycobacterium Tuberculosis | |
dc.type | info:eu-repo/semantics/article | |
dc.relation.journal | Scientific Reports | |
dc.contributor.department | Tıbbi Mikrobiyoloji | |
dc.identifier.volume | 6 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |