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dc.contributor.authorNacar, Ahmet
dc.contributor.authorKaraboga, Ihsan
dc.contributor.authorOkuyan, Hamza Malik
dc.contributor.authorKaplan Sefil, Nebihat
dc.contributor.authorNacar, Emel
dc.contributor.authorMotor, Sedat
dc.contributor.authorAkkucuk, Seckin
dc.contributor.authorOzkan, Orhan Veli
dc.date.accessioned2019-12-12T06:25:07Z
dc.date.available2019-12-12T06:25:07Z
dc.date.issued2015
dc.identifier.issn1300-0144
dc.identifier.urihttps://doi.org/10.3906/sag-1404-6
dc.identifier.urihttp://hdl.handle.net/11655/16250
dc.description.abstractBackground/aim: In the present study, the protective effect of erdosteine against cyclosporine-induced injury in rat liver was investigated with histological and biochemical methods. Materials and methods: Thirty-two Wistar albino male rats were randomly divided into 4 groups: control (n = 8), cyclosporine (n = 8, 20 mg kg(-1) day(-1) i.p.), cyclosporine + erdosteine (n = 8, erdosteine 12 mg kg(-1) day(-1) orally), and erdosteine (n = 8). At the end of day 12, liver tissues were removed for histological and biochemical analysis. After liver tissues were fixed in 10% buffered neutral formalin, routine histological processes were applied and tissue sections were stained with hematoxylin and eosin, periodic acid-Schiff, and elastic fiber stain methods. One hundred lobules of liver were examined for each group and evaluated statistically. The levels of malondialdehyde and glutathione peroxidase, as well as the activities of superoxide dismutase, were determined. Results: The cyclosporine group showed significant histopathological changes compared to the control. In the cyclosporine + erdosteine group, histopathological changes of hepatic damage were markedly reduced. Histological findings were supported by biochemical results. Conclusion: Erdosteine could attenuate cyclosporine-induced liver injury.
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.isversionof10.3906/sag-1404-6
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGeneral & Internal Medicine
dc.titleInvestigation of the Protective Effect of Erdosteine Against Cyclosporine-Induced Injury in Rat Liver with Histological and Biochemical Methods
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalTurkish Journal Of Medical Sciences
dc.contributor.departmentTıp Tarihi ve Etik
dc.identifier.volume45
dc.identifier.issue6
dc.identifier.startpage21-Oct
dc.identifier.endpage1395
dc.description.indexWoS
dc.description.indexScopus


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