dc.contributor.author | Gultekin, Hulya | |
dc.contributor.author | Erdem, S. Remzi | |
dc.contributor.author | Emre-Aydingoz, Selda | |
dc.contributor.author | Tuncer, Metal | |
dc.date.accessioned | 2019-12-10T11:32:41Z | |
dc.date.available | 2019-12-10T11:32:41Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 1347-8613 | |
dc.identifier.uri | https://doi.org/10.1254/jphs.FP0060159 | |
dc.identifier.uri | http://hdl.handle.net/11655/16050 | |
dc.description.abstract | The aim of this study was to investigate the modulatory role of nitric oxide (NO) in the electrical field stimulation (EFS)-induced contractions of isolated sphincter of Oddi (SO) and gallbladder strips from guinea pigs. EFS was used to activate the intrinsic nerves in SO and gallbladder strips. EFS produced frequency-dependent biphasic contractile responses in the SO strips. A smaller contraction, "on response", occurred during EFS, which was followed, by a bigger contraction, "off response". Both responses were completely and irreversibly abolished by tetrodotoxin (TTX) (10(-6) M). Atropine (10(-6) M) inhibited the "on response", but not the "off response". EFS produced frequency-dependent monophasic contractile responses in gallbladder strips, which were completely and irreversibly abolished by TTX (10(-6) M) and atropine (10(-6) M). A nitric oxide synthase (NOS) inhibitor, N-G-nitro-L-arginine (10(-4) M and 3 x 10(-4) M, in SO and gallbladder strips, respectively), significantly increased all EFS-induced contractions of SO and gallbladder strips. L-Arginine, but not D-arginine reversed the effect induced by the NOS inhibitor, at all frequencies, in both strips. These results suggested that NO released from nitrergic nerve endings might play a regulatory role in the cholinergic neurotransmission of guinea pig SO and gallbladder strips. The "off response" in the SO preparations might be a rebound increase that was modulated by the nonadrenergic, noncholinergic inhibitory mediator NO. | |
dc.language.iso | en | |
dc.publisher | Japanese Pharmacological Soc | |
dc.relation.isversionof | 10.1254/jphs.FP0060159 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Pharmacology & Pharmacy | |
dc.title | The Role Of Nitric Oxide In The Electrical Field Stimulation-Induced Contractions Of Sphincter Of Oddi And Gallbladder Strips In Guinea Pigs | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Journal Of Pharmacological Sciences | |
dc.contributor.department | Tıbbi Farmakoloji | |
dc.identifier.volume | 101 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 240 | |
dc.identifier.endpage | 244 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |