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Inherited And Acquired Immunodeficiencies Underlying Tuberculosis In Childhood
(Wiley, 2015)
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb) and a few related mycobacteria, is a devastating disease, killing more than a million individuals per year worldwide. However, its pathogenesis remains largely ...
Revisiting Human Il-12R Beta 1 Deficiency A Survey Of 141 Patients From 30 Countries
(Lippincott Williams & Wilkins, 2010)
Interleukin-12 receptor beta 1 (IL-12R beta 1) deficiency is the most common form of Mendelian susceptibility to mycobacterial disease (MSMD). We undertook an international survey of 141 patients from 102 kindreds in 30 ...
Mycobacterial Disease And Impaired Ifn-Gamma Immunity In Humans With Inherited Isg15 Deficiency
(Amer Assoc Advancement Science, 2012)
ISG15 is an interferon (IFN)-alpha/beta-inducible, ubiquitin-like intracellular protein. Its conjugation to various proteins (ISGylation) contributes to antiviral immunity in mice. Here, we describe human patients with ...