Sağlıklı Bireylerde Geleneksel Üzüm İçeceği Hardaliyenin Serum Antioksidan ve Biyokimyasal Parametreler Üzerine Etkisi
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Hardaliye is a traditional, fermented, and alcohol-free beverage that its own history spans hundred of years. Hardaliye is a grape beverage considered to have antioxidative effects as a potential source of bioactive components. This study is a randomised controlled intervention trial, aimed to investigate the effects of daily dietary supplementation with hardaliye on some antioxidant and biochemical parameters of healthy individuals. Eighty nine healthy adults were participated into the study and participants were randomised and divided into three groups: group 1, group 2 and control. The two groups, except control group were consumed hardaliye (group 1: 500 mL/day, group 2: 250 mL/day) during 6 weeks. Some oxidant, antioxidant and biochemical parameters were analysed in collected blood samples, and anthropometric and blood pressure measurements were performed both at baseline and after intervention. At the end of this study, effects of hardaliye on anthropometric measurements, blood pressure, general biochemical parameters and serum minerals were not found statistically important (p>0.05), while non-significant increase was observed for serum total antioxidant capacity and vitamin C (p>0.05). Significant decreases in the level of some oxidative stress indicators [dien conjugate (DC), malodialdehyde (MDA) and homocysteine] were observed in group 1 and group 2 (p<0.001). The effects of hardaliye on DC, MDA and homocysteine might be due to its phenolic compounds. The results of this study indicate a dose response that was only observed for homocysteine and support the antioxidative effects of hardaliye on some oxidative stress parameters. Further studies need to be performed to better assess the antioxidant properties and dose effects of hardaliye.