In Vitro Activities Of Antibiotics Alone And In Combination Against Brucella Melitensis At Neutral And Acidic Phs
Date
1999Author
Akova, M
Gur, D
Livermore, DM
Kocagoz, T
Akalin, HE
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Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pH 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxcycline and rifampin-doxycycline combinations.