In Vitro Activities Of Antibiotics Alone And In Combination Against Brucella Melitensis At Neutral And Acidic Phs
Özet
Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pH 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxcycline and rifampin-doxycycline combinations.