Serotype Distribution of Streptococcus Pneumoniae in Children with Invasive Diseases in Turkey: 2008-2014
Tarih
2016Yazar
Ceyhan, Mehmet
Özsürekci, Yasemin
Gürler, Nezahat
Öksüz, Lutfiye
Aydemir, Sohret
Özkan, Sengül
Yüksekkaya, Serife
Emiroglu, Melike Keser
Gültekin, Meral
Yaman, Akgün
Kiremitci, Abdurrahman
Yanik, Keramettin
Karlı, Arzu
Özcinar, Hatice
Aydın, Faruk
Bayramoğlu, Gülcin
Zer, Yasemin
Gülay, Zeynep
Gayyurhan, Efgan Doğan
Gül, Mustafa
Özakin, Cüneyt
Güdücuoğlu, Hüseyin
Percin, Duygu
Akpolat, Nezahat
Öztürk, Candan
Camcıoglu, Yıldız
Öncel, Eda Karadağ
Celik, Melda
Sanal, Laser
Uslu, Hakan
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Successful vaccination policies for protection from invasive pneumococcal diseases (IPD) dependent on determination of the exact serotype distribution in each country. We aimed to identify serotypes of pneumococcal strains causing IPD in children in Turkey and emphasize the change in the serotypes before and after vaccination with 7-valent pneumococcal conjugate vaccine (PCV-7) was included and PCV-13 was newly changed in Turkish National Immunization Program. Streptococcus pneumoniae strains were isolated at 22 different hospitals of Turkey, which provide healthcare services to approximately 65% of the Turkish population. Of the 335 diagnosed cases with S. pneumoniae over the whole period of 2008-2014, the most common vaccine serotypes were 19F (15.8%), 6B (5.9%), 14 (5.9%), and 3 (5.9%). During the first 5y of age, which is the target population for vaccination, the potential serotype coverage ranged from 57.5 % to 36.8%, from 65.0% to 44.7%, and from 77.4% to 60.5% for PCV-7, PCV-10, and PCV-13 in 2008-2014, respectively. The ratio of non-vaccine serotypes was 27.2% in 2008-2010 whereas was 37.6% in 2011-2014 (p=0.045). S. penumoniae serotypes was less non-susceptible to penicillin as compared to our previous results (33.7vs 16.5 %, p=0.001). The reduction of those serotype coverage in years may be attributed to increasing vaccinated children in Turkey and the increasing non-vaccine serotype may be explained by serotype replacement. Our ongoing IPD surveillance is a significant source of information for the decision-making processes on pneumococcal vaccination.