Loss of Maternal Allele in a Child with Myelodysplastic Syndrome and Monosomy 7
Özet
Monosomy 7 or partial deletion of the long arm of chromosome 7 is frequently described in children with myelodysplastic syndrome and acute myeloblastic leukemia, Parental origin of chromosome 7 in children with sporadic monosomy 7 has been examined very rarely, To investigate if monosomy 7 shows parent-of-origin, we have studied a female child with monosomy 7 and de novo myelodysplastic syndrome by a series of polymorphic polymerase chain reaction markers. We found loss of maternal allele and discussed the results with the previous reports. Am, J, Hematol. 62:49-51, 1999. (C) 1999 Wiley-Liss, Inc.
Bağlantı
https://doi.org/10.1002/(SICI)1096-8652(199909)62:1<49::AID-AJH8>3.3.CO;2-Phttp://hdl.handle.net/11655/14137