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dc.contributor.authorOzen, Seza
dc.contributor.authorKone-Paut, Isabelle
dc.contributor.authorGul, Ahmet
dc.date.accessioned2019-12-10T10:35:19Z
dc.date.available2019-12-10T10:35:19Z
dc.date.issued2017
dc.identifier.issn0049-0172
dc.identifier.urihttps://doi.org/10.1016/j.semarthrit.2017.03.006
dc.identifier.urihttp://hdl.handle.net/11655/13862
dc.description.abstractBackground: Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory syndrome characterized by recurrent serositis or arthritis attacks and, in some patients, chronic subclinical inflammation that predisposes to secondary amyloidosis. Colchicine is the gold standard of treatment, which reduces attack frequency and amyloidosis risk. However, up to 5% of patients are considered resistant or inadequately respond to colchicine, and some others cannot tolerate the side effects of effective doses of colchicine (colchicine intolerant). Methods: We examine how the definition of colchicine resistance has evolved along with various characteristics of colchicine that may help explain unresponsiveness to the drug. Results: Key factors in assessing colchicine resistance include attack frequency and severity, levels of acute phase reactants, colchicine dosage and composition, and treatment compliance. Promising clinical results have been obtained with biologics targeting interleukin-1 in colchicine-resistant or -intolerant patients with FMF. Conclusions: These results underscore the need to identify patients who are not optimally managed with colchicine and who might therefore benefit from additional biologic therapies. (C) 2017 The Authors. Published by Elsevier HS Journals, Inc.
dc.language.isoen
dc.publisherW B Saunders Co-Elsevier Inc
dc.relation.isversionof10.1016/j.semarthrit.2017.03.006
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRheumatology
dc.titleColchicine Resistance And Intolerance In Familial Mediterranean Fever: Definition, Causes, And Alternative Treatments
dc.typeinfo:eu-repo/semantics/review
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalSeminars In Arthritis And Rheumatism
dc.contributor.departmentÇocuk Sağlığı ve Hastalıkları
dc.identifier.volume47
dc.identifier.issue1
dc.identifier.startpage115
dc.identifier.endpage120
dc.description.indexWoS
dc.description.indexScopus


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