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The Effect of Melatonın on Hıppo Sıgnallıng Pathway in Dental Pulp Stem Cells
(Sağlık Bilimleri Enstitüsü, 2020)
Dental pulp stem cells (DPSCs) are heterogeneous multipotent adult stem cells with high capacity to differentiate to both neuronal and non-neuronal cell lineage. Hippo pathway regulates diverse cellular processes, including ...
Kişiselleştirilmiş Sağkalım Tahmini İçin Geniş Çaplı Kanser Verisinin Yapay Öğrenme ve Çoklu-Omik Bazlı Analizi
(Sağlık Bilimleri Enstitüsü, 2022)
Cancer is one of the leading causes of death worldwide. The high lethality of some of the sub-types of cancer increases the importance of correct diagnosis, complete follow-up and effective treatment. Survivability in ...
Hematopoetik Kök Hücre Gen Tedavi Kültür Koşulları ve Engraftman Optimizasyonu
(Sağlık Bilimleri Enstitüsü, 2021)
RAG2 severe combined immunodeficiency (SCID) is a rare, inherited primary immunodeficiency (PID), characterized by a T-/B-/NK+ phenotype and is treated with hematopoietic stem cell (HSC) transplantation. When no suitable ...
Methionine Metabolism in Human Fetal, Adult and Cancer Stem Cells
(Sağlık Bilimleri Enstitüsü, 2021-08-09)
Methionine is an essential amino acid critical in protein synthesis and methylation reactions. In this thesis, it is aimed to determine the effect of methionine on different human stem cell groups. Mesenchymal stem cells ...
Image, Sequence, and Interactome Based Prediction of Subcellular Localization of Proteins
(Sağlık Bilimleri Enstitüsü, 2024-01-31)
Knowledge of subcellular localization (SL) of proteins is essential for drug
development, systems biology, proteomics, and functional genomics. Due to the high
costs associated with experimental studies, it has become ...