Browsing Sağlık Bilimleri Enstitüsü by Issue Date
Now showing items 21-40 of 93
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Characterization of Acute Myeloid Leukemia Stem Cells By Niche-Like Coculture System
(Sağlık Bilimleri Enstitüsü, 2019)AML heterogeneity show evidence of hierarchical cellular organization and at the top of this hierarchical structure there is a rare group of LSCs. It was mentioned that there is an association between LSCs and disease ... -
Non-Segmental Vitiligo ile HLA Genotipi Ve Oksidatif Stres Arasındaki İlişki
(Sağlık Bilimleri Enstitüsü, 2019)Vitiligo is an autoimmune skin diseases characterized by acquired loss of functional melanocytes. Although the pathogenesis of vitiligo remains poorly understood, oxidative stress and autoimmune disregulations are considered ... -
İnsan Göbek Kordon Veni CD146+ Hücrelerin ve Bu Hücrelerden Elde Edilen Matriks Proteinlerinin in vitro Biyofilm Modellerinde Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2019)In the treatment of wounds, the application of cells or decellularized matrices with antimicrobial effects to the wound area has attracted attention in recent years. The aim of this thesis is to evaluate CD146+ stem cells ... -
İnfantil Osteopetrozisli Hasta Uyarılmış Pluripotent Kök Hücreleri ile Osteoklast Defektinin Modellenmesi,Osteoklast ve Hematopoietik Niş İlişkisi
(Sağlık Bilimleri Enstitüsü, 2019)Malignant infantile osteopetrosis is an autosomal recessive disorder. The only available treatment is allogeneic hematopoietic stem cell transplantation. The objective of this study was to model hematopoietic niche in ... -
Kemik İliği Mezenkimal Kök Hücrelerinde PKNOX2 Proteinin ATM ve RNF8 Proteinleri ile Etkileşimlerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2019)Donmez, N., Investigation of PKNOX2 Protein Interactions with ATM and RNF8 in Bone Marrow Derived Mesenchymal Stem Cells, Hacettepe University Graduate School Health Sciences Stem Cell Program Master Thesis, Ankara, 2019. ... -
Volumetrik Rinoplasti Konsepti Ve Düşük İle Yüksek Başlangıçlı Lateral Osteotomi Uygulanan Redüksiyon Rinoplasti Hastalarında Karşılaştırılması
(2019-09-18)Burun estetiğinin burundan nefes alma üzerine etkisi, literatürde onlarca yıldır tartışılan bir konudur. Bu konuyu aydınlatmak adına randomize prospektif kontrol bir klinik çalışma planlanmıştır. Burundan nefes alma problemi ... -
Paramedik Programı Öğrencilerinin Triyaj Yönetiminde Görsel Olarak Geliştirilmiş Zihinsel Simülasyonun Etkililiği
(Sağlık Bilimleri Enstitüsü, 2020)Demir, S., The Effectiveness of Visually Enhanced Mental Simulation in Triage Management of Paramedic Program Students. Hacettepe University Institute of Health Sciences Simulation Program in Health Sciences Master's Thesis, ... -
The Effect of Melatonın on Hıppo Sıgnallıng Pathway in Dental Pulp Stem Cells
(Sağlık Bilimleri Enstitüsü, 2020)Dental pulp stem cells (DPSCs) are heterogeneous multipotent adult stem cells with high capacity to differentiate to both neuronal and non-neuronal cell lineage. Hippo pathway regulates diverse cellular processes, including ... -
Geriatrik Vakalarda Yüksek Frekanslarda İzlenen Hava Kemik Aralığın Geniş Bant Timpanometri ve DPOAE Yanıtlarına Etkisi
(Sağlık Bilimleri Enstitüsü, 2020)Some anatomical, histological, and physiological changes occur in the external and middle ear depending on aging. In this study, we investigated the wideband tympanometry results of elderly people and different old age ... -
Fındık Alerjeninin Çapraz Kontaminasyon Yolaklarının Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2020-01-28)Cross-contamination is a major source of hidden allergens in foods and can occur at all food processing stages. The aim of this study was to investigate contamination pathways and the contamination levels of hazelnut ... -
Mezenkimal Kök Hücre Üretiminde İn Vitro Temelli Metabolomik ve Analizler
(Sağlık Bilimleri Enstitüsü, 2020-02-12)Karaağaç Akyol, T. Metabolomic And Analyzes In In-Vitro Based On The Production Of Mesenchimal Stem Cells, Hacettepe University Graduate School of Health Sciences Stem Cells Program Doctor of Philosophy Thesis, Ankara, ... -
Uyarılmış Pluripotent Kök Hücrelerin Araştırma Amaçlı Bankalanmasında Standardizasyon ve Kalite Süreci - Bir Uygulama Modeli: “Pedı-Stem”
(Sağlık Bilimleri Enstitüsü, 2020-06-18)Induced pluripotent stem cell (iPSC) is generated by genetic modification of any cell type of the body in laboratory conditions by transferring of embryonic stem cell-like pluripotent properties. iPSC is a cell model that ... -
Kemik İliği Yağ Tabakasından Elde Edilen Mezenkimal Kök Hücrelerin Karakterizasyonu ve Subkutan Yağ ve Kemik İliği Kökenli Mezenkimal Kök Hücreleri ile Karşılaştırılması
(Sağlık Bilimleri Enstitüsü, 2020-09)Bone marrow adipose tissue (BMAT) has different properties than other adipose tissues. Recent studies have shown the effects of bone marrow adipose tissue on development / progression of acute myeloblastic leukemia (AML), ... -
Ergenlerin ve Ailelerinin Şiddete Yönelik İnanç ve Tutumlarinin Ergenlerin Şiddet Davranışlarına Etkileri
(Sağlık Bilimleri Enstitüsü, 2021)This study aims to create a set of data in order to find possible links between adolescents' violent behaviours and adolescents' and their families' beliefs and attitudes towards violence. Buss-Perry aggression scale (BPSS) ... -
Mezenkimal Kök Hücre Yaşlanmasında Nf-Κb/P65 ve Pknox2 Protein-Protein Etkileşimlerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2021)Mesenchymal stem cells undergo replicative senescence by cultivating in vitro and as the passage extends they lose their stem cell properties. Previous study of our group investigating proteomics of the co-immunoprecipitated ... -
Bayesian Networks for Omics Data Analysis in Hepatocellular Carcinoma Single-Cell Sequencing
(Sağlık Bilimleri Enstitüsü, 2021)Single cell multi omics techniques have shown an advancement in unrevealing complex diseases like cancer heterogeneity by providing multi-faceted insight into their individual cellular regulations. In this study, a machine ... -
The Perceptions of Healthcare Professionals Serving Migrant, Refugee and Asylum Seekers in the Primary Healthcare Centers of Hatay, Şanlıurfa, Gaziantep and İzmir About Healthcare Provision, and Their Level of Burnout
(Halk Sağlığı Enstitüsü, 2021)Objective: The purpose of this study is to investigate the level of burnout and perceptions of health professionals serving in primary healthcare centers in four provinces in Turkey, namely Gaziantep, Hatay, İzmir, ... -
Hematopoetik Kök Hücre Gen Tedavi Kültür Koşulları ve Engraftman Optimizasyonu
(Sağlık Bilimleri Enstitüsü, 2021)RAG2 severe combined immunodeficiency (SCID) is a rare, inherited primary immunodeficiency (PID), characterized by a T-/B-/NK+ phenotype and is treated with hematopoietic stem cell (HSC) transplantation. When no suitable ... -
Dört Farklı Kansere Ait Transkriptom Verisinin In Sılıco Karşılaştırılması ve Pankreas Kanserine Özgü Biyobelirteç Adaylarının Belirlenmesi
(Sağlık Bilimleri Enstitüsü, 2021-02-23)Pancreatic cancer is the 11th most common cancer worldwide. Five-year survival of lung, colon and stomach cancers, which are the top three in cancer related deaths, are 19%, 65% and 20%, respectively. Although pancreatic ... -
Methionine Metabolism in Human Fetal, Adult and Cancer Stem Cells
(Sağlık Bilimleri Enstitüsü, 2021-08-09)Methionine is an essential amino acid critical in protein synthesis and methylation reactions. In this thesis, it is aimed to determine the effect of methionine on different human stem cell groups. Mesenchymal stem cells ...