Ara
Toplam kayıt 22, listelenen: 1-10
Nog Gen İfadesi Susturulmuş Hücrelerin Oluşturulması ve İpek Doku İskeleleri Üzerinde Osteojenik Farklılaşmalarının İncelenmesi
(Fen Bilimleri Enstitüsü, 2020-12-01)
This study was funded by Hacettepe University Scientific Research Projects Coordination Unit (BAP) graduate project entitled "Generation of Nog Knockout Cells by CRISPR/Cas9 Mediated Genome Editing and Examination of Their ...
Mikrotübül İnhibitörlerinin Kanser Hücrelerinde Tehlike-İlişkili Moleküler Desen Düzeylerine Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2020)
Cancer cells are proliferate rapidly and uncontrolled. Chemotherapeutics such as vinorelbine and colchicine affect the cell cycle and DNA synthesis mechanism; they causes cells to be kept in the G2 / M phase by preventing ...
Kemik İliği Yağ Tabakasından Elde Edilen Mezenkimal Kök Hücrelerin Karakterizasyonu ve Subkutan Yağ ve Kemik İliği Kökenli Mezenkimal Kök Hücreleri ile Karşılaştırılması
(Sağlık Bilimleri Enstitüsü, 2020-09)
Bone marrow adipose tissue (BMAT) has different properties than other adipose tissues. Recent studies have shown the effects of bone marrow adipose tissue on development / progression of acute myeloblastic leukemia (AML), ...
Mezenkimal Kök Hücre Yaşlanmasında Nf-Κb/P65 ve Pknox2 Protein-Protein Etkileşimlerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2021)
Mesenchymal stem cells undergo replicative senescence by cultivating in vitro and as the passage extends they lose their stem cell properties. Previous study of our group investigating proteomics of the co-immunoprecipitated ...
The Role of Regnase-1 Protein in Sculpting of Tumor Microenvironment
(Kanser Enstitüsü, 2021)
The tumor microenvironment (TME) contains cancer-associated fibroblasts (CAFs) and their tumor-supportive role helps to build an environment in favor of cancer cell progression. Recent researches have revealed that targeting ...
İn Vitro Diyagnostik Sistemlerde Kullanılmak Üzere Yeni Nesil Elektrotların Tasarımı ve Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2021)
This study aims to fabricate electrodes with properties of both gold and diamond-like carbon (DLC) thin films for in vitro diagnostic system applications for the first time. A specific self-assembly method was used to ...
Hücre Ölüm Yolaklarının Tespiti İçin Kağıt Tabanlı Biyosensör Tasarımı
(Fen Bilimleri Enstitüsü, 2021)
The aim of the presented thesis, a paper-based biosensor design has been designed to be
used in the detection of early (extrinsic pathway) and late (instrinsic pathway) stages of
apoptosis. In the study, in order to ...
İlaç Salımı için Mitomisin C Baskılanmış Manyetik Partikül Gömülü Kriyojellerin Hazırlanması
(Fen Bilimleri Enstitüsü, 2020)
Controlled drug release is a technique used for releasing the drug in the desired site of the body at the therapeutic dose. In drug release systems, administration of the drug given to the patient in appropriate doses to ...
Apc Mutant Fare İntestinal Organoidlerinde Wnt Yolak Modülasyonunun Kök Hücreler Üzerine Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2022)
One of the most important causes of colorectal cancer development is mutations of genes involved in the WNT signaling pathway. In the vast majority of cases, APC tumor suppressor gene mutations, which act as negative ...
Pankreas Kanseri Hücre Hattında TFAM Ekspresyon Düzeyinin Hücre Fonksiyonları Üzerine Etkisi
(Kanser Enstitüsü, 2022-07-29)
Pancreatic cancer is an aggressive malignancy with a poor prognosis. Early diagnosis and application of tumor-specific treatment are very important in pancreatic cancer. Therefore, new biomarkers are needed in the diagnosis ...