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Identification Of A Founder Mutation In Tpm3 In Nemaline Myopathy Patients Of Turkish Origin
(Nature Publishing Group, 2008)
To date, six genes are known to cause nemaline (rod) myopathy (NM), a rare congenital neuromuscular disorder. In an attempt to find a seventh gene, we performed linkage and subsequent sequence analyses in 12 Turkish families ...
In Vivo And In Vitro Effects Of A Hif-1 Alpha Inhibitor, Rx-0047
(Wiley, 2008)
HIF-1 alpha plays a major role in activating gene transcription and is important for maintaining homeostasis under hypoxic conditions. Since tumors are often in a hypoxic state, HIF-1 alpha is a potential target for the ...
Blockade of Gaba Synthesis Only Affects Neural Excitability Under Activated Conditions in Rat Hippocampal Slices
(Pergamon-Elsevier Science Ltd, 2008)
The primary goal of this study was to establish whether inhibition of GABA synthesis was sufficient to induce network hyperexcitability in a rat hippocampal slice model comparable to that seen with GABA receptor blockade. ...