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Pinealectomy Aggravates and Melatonin Administration Attenuates Brain Damage in Focal Ischemia
(Sage Publications Inc, 1999)
Large infarcts develop in pinealectomized rats subjected to middle cerebral artery occlusion, which was attributed to loss of antioxidant action of melatonin. However, melatonin also has vascular actions, and pinealectomy ...
Mechanisms Of Motor Dysfunction After Transient Mca Occlusion - Persistent Transmission Failure In Cortical Synapses Is A Major Determinant
(Lippincott Williams & Wilkins, 1998)
Background and Purpose-Failure of prompt motor recovery after spontaneous recirculation or thrombolytic therapy may be due to an unsatisfactory restoration of synaptic activity within cortex and/or blockade of electrical ...
Prolonged Therapeutic Window for Ischemic Brain Damage Caused by Delayed Caspase Activation
(Sage Publications Inc, 1998)
Apoptotic cell death is prominent in neurodegenerative disorders, such as Alzheimer's disease and Huntington's disease? and is found in cerebral ischemia. Using a murine model of delayed cell death, we determined that ...