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Toplam kayıt 39, listelenen: 21-39
Unliganded Estrogen Receptor-Alpha Activates Transcription Of The Mammary Gland Na+/I- Symporter Gene
(Academic Press Inc Elsevier Science, 2006)
The function of sodium iodide symporter (Na+/I- symporter, or NIS) in mammary epithelial cells is essential for the accumulation of I- in milk; the newborn's first source of I- for thyroid hormone synthesis. Furthermore ...
Lipoxygenase-3 (Aloxe3) and 12(R)-Lipoxygenase (Alox12B) Are Mutated in Non-Bullous Congenital Ichthyosiform Erythroderma (Ncie) Linked to Chromosome 17P13.1
(Oxford Univ Press, 2002)
We report the identification of mutations in lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) genes in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17. Linkage disequilibrium analysis ...
L-2-Hydroxyglutaric Aciduria: Identification of a Mutant Gene C14Orf160, Localized on Chromosome 14Q22.1
(Oxford Univ Press, 2004)
l-2-Hydroxyglutaric aciduria (l-2-HGA) is characterized by progressive deterioration of central nervous system function including epilepsy and macrocephaly in 50% of cases, and elevated levels of l-2-hydroxyglutaric acid ...
Mutations In Ichthyin A New Gene On Chromosome 5Q33 In A New Form Of Autosomal Recessive Congenital Ichthyosis
(Oxford Univ Press, 2004)
We report the genomic localization by homozygosity mapping and the identification of a gene for a new form of non-syndromic autosomal recessive congenital ichthyosis. The phenotype usually presents as non-bullous congenital ...
The Mutational Spectrum Of Human Malignant Autosomal Recessive Osteopetrosis
(Oxford Univ Press, 2001)
Human malignant infantile osteopetrosis (arOP; MIM 259700) is a genetically heterogenous autosomal recessive disorder of bone metabolism, which, if untreated, has a fatal outcome. Our group, as well as others, have recently ...
Activation-Induced Cytidine Deaminase (AID) Deficiency Causes The Autosomal Recessive Form Of The Hyper-Igm Syndrome (HIGM2)
(Cell Press, 2000)
The activation-induced cytidine deaminase (AID) gene, specifically expressed in germinal center B cells in mice, is a member of the cytidine deaminase family. We herein report mutations in the human counterpart of AID in ...
Automated Discrimination of Psychotropic Drugs in Mice Via Computer Vision-Based Analysis
(Elsevier Science Bv, 2009)
We developed an inexpensive computer vision-based method utilizing an algorithm which differentiates drug-induced behavioral alterations. The mice were observed in an open-field arena and their activity was recorded for ...
In Vivo And In Vitro Effects Of A Hif-1 Alpha Inhibitor, Rx-0047
(Wiley, 2008)
HIF-1 alpha plays a major role in activating gene transcription and is important for maintaining homeostasis under hypoxic conditions. Since tumors are often in a hypoxic state, HIF-1 alpha is a potential target for the ...
Synthesis, Antioxidant and Radical Scavenging Activities of Novel Benzimidazoles
(Taylor & Francis Ltd, 2005)
The synthesis and antioxidant evaluation of some novel benzimidazole derivatives (10-24) are described. Antioxidant properties of the compounds were investigated employing various in vitro systems viz., microsomal ...
Neopterin Profile To Evaluate The Effectiveness Of Treatment In Aggressive Periodontitis
(Walter De Gruyter Gmbh, 2003)
Periodontal disease results from the interaction of the host defence mechanisms with the microbial dental plaque. Analysis of gingival crevicular fluid (GCF) provides a non-invasive means of evaluating the role of the host ...
Three Acylated Flavone Glycosides From Sideritis Ozturkii Aytac & Aksoy
(Pergamon-Elsevier Science Ltd, 2004)
From the aerial parts of Sideritis ozturkii, three new flavonoids, chrysoeriol 7-O-[2"'-O-calieoyl-6"'-O-acetyl-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranoside], chrysoeriol 7-O-[2"'-O-cafeoyl-beta-O-glucopyranosyl-(1 ...
Synthesis and Antioxidant Properties of Novel Benzimidazole Derivatives
(Taylor & Francis Ltd, 2004)
Some novel benzimidazole derivatives carrying thiosemicarbazide and triazole moieties at the N1 position were synthesized and their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels ...
Synchrotron Ft-Ir Microspectroscopic Analysis of Necrotic Bone
(Hindawi Ltd, 2007)
Avascular necrosis (osteonecrosis) is a disease that results from the temporary or permanent loss of blood supply to the bone. Synchrotron FT-IR microspectroscopy has been used to study the changes in mineral and matrix ...
Xeroderma Pigmentosum Complementation Group E Protein (Xpe/Ddb2): Purification Of Various Complexes Of Xpe And Analyses Of Their Damaged Dna Binding And Putative Dna Repair Properties
(Amer Soc Microbiology, 2005)
Xeroderma pigmentosum is characterized by increased sensitivity of the affected individuals to sunlight and light-induced skin cancers and, in some cases, to neurological abnormalities. The disease is caused by a mutation ...
Time-Frequency Component Analyser And Its Application To Brain Oscillatory Activity
(Elsevier Science Bv, 2005)
Currently, event-related potential (ERP) signals are analysed in the time domain (ERP technique) or in the frequency domain (Fourier analysis and variants). In techniques of time-domain and frequency-domain analysis ...
Intelligent Polymers as Nonviral Vectors
(Nature Publishing Group, 2005)
The successful gene therapy largely depends on the vector type that allows a selective and efficient gene delivery to target cells with minimal toxicity. Nonviral vectors are much safer and cheaper, can be produced easily ...
Blockade of Gaba Synthesis Only Affects Neural Excitability Under Activated Conditions in Rat Hippocampal Slices
(Pergamon-Elsevier Science Ltd, 2008)
The primary goal of this study was to establish whether inhibition of GABA synthesis was sufficient to induce network hyperexcitability in a rat hippocampal slice model comparable to that seen with GABA receptor blockade. ...
Tamoxifen Increases Membrane Fluidity at High Concentrations
(Kluwer Academic/Plenum Publ, 2000)
There are contradictory results in the literature relating to the effect of tamoxifen on membrane fluidity. The present work investigates the effect of tamoxifen on membrane dynamics to find out whether the concentration ...