Ara
Toplam kayıt 7, listelenen: 1-7
Cpg Methylation In The Fhit Regulatory Region: Relation To Fhit Expression In Murine Tumors
(Nature Publishing Group, 2004)
To determine if: (1) 5' CpG island methylation is related to Fhit inactivation; (2) there are tumor or carcinogen-specific methylation patterns, we examined 35 CpG sites in the promoter, exon and intron 1 of the mouse Fhit ...
Targeting Critical Steps of Cancer Metastasis and Recurrence Using Telomerase Template Antagonists
(Elsevier Science Bv, 2009)
Metastasis, tumor relapse, and drug resistance remain major obstacles in the treatment of cancer. Therefore, more research on the mechanisms of these processes in disease is warranted for improved treatment options. Recent ...
Artemis, A Novel Dna Double-Strand Break Repair/V(D)J Recombination Protein, Is Mutated In Human Severe Combined Immune Deficiency
(Cell Press, 2001)
The V(D)J recombination process insures the somatic diversification of immunoglobulin and antigen T cell receptor encoding genes. This reaction is initiated by a DNA double-strand break (dsb), which is resolved by the ...
Activation-Induced Cytidine Deaminase (AID) Deficiency Causes The Autosomal Recessive Form Of The Hyper-Igm Syndrome (HIGM2)
(Cell Press, 2000)
The activation-induced cytidine deaminase (AID) gene, specifically expressed in germinal center B cells in mice, is a member of the cytidine deaminase family. We herein report mutations in the human counterpart of AID in ...
In Vivo And In Vitro Effects Of A Hif-1 Alpha Inhibitor, Rx-0047
(Wiley, 2008)
HIF-1 alpha plays a major role in activating gene transcription and is important for maintaining homeostasis under hypoxic conditions. Since tumors are often in a hypoxic state, HIF-1 alpha is a potential target for the ...
Xeroderma Pigmentosum Complementation Group E Protein (Xpe/Ddb2): Purification Of Various Complexes Of Xpe And Analyses Of Their Damaged Dna Binding And Putative Dna Repair Properties
(Amer Soc Microbiology, 2005)
Xeroderma pigmentosum is characterized by increased sensitivity of the affected individuals to sunlight and light-induced skin cancers and, in some cases, to neurological abnormalities. The disease is caused by a mutation ...
Tamoxifen Increases Membrane Fluidity at High Concentrations
(Kluwer Academic/Plenum Publ, 2000)
There are contradictory results in the literature relating to the effect of tamoxifen on membrane fluidity. The present work investigates the effect of tamoxifen on membrane dynamics to find out whether the concentration ...