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Pinealectomy Aggravates and Melatonin Administration Attenuates Brain Damage in Focal Ischemia
(Sage Publications Inc, 1999)
Large infarcts develop in pinealectomized rats subjected to middle cerebral artery occlusion, which was attributed to loss of antioxidant action of melatonin. However, melatonin also has vascular actions, and pinealectomy ...
Reperfusion-Induced Oxidative/Nitrative Injury To Neurovascular Unit After Focal Cerebral Ischemia
(Lippincott Williams & Wilkins, 2004)
Background and Purpose-Use of thrombolysis in stroke is limited by a short therapeutic window because delayed reperfusion may cause brain hemorrhage and edema. Available evidence suggests a role for superoxide, NO, and ...
Vegf Protects Brain Against Focal Ischemia Without Increasing Blood-Brain Permeability When Administered Intracerebroventricularly
(Sage Publications Inc, 2005)
Delayed administration of vascular endothelial growth factor (VEGF) promotes functional recovery after focal cerebral ischemia. However, early intravenous injection of VEGF increases blood-brain barrier (BBB) leakage, ...