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Genetic Predisposition To Fiber Carcinogenesis Causes A Mesothelioma Epidemic In Turkey
(Amer Assoc Cancer Research, 2006)
Malignant mesothelioma in the western world is often associated with asbestos exposure. It is a relatively rare cancer that causes similar to 2,500 deaths yearly in the United States and 1,000 deaths yearly in the United ...
Life-Threatening Neurological Complications after Bone Marrow Transplantation in Children
(Nature Publishing Group, 2005)
Neurological complications may occur in BMT recipients (11-59%), frequently contributing to morbidity or mortality. They are the main causes of death in 10-15%. Life-threatening neurological complications were seen in 11 ...
In Vivo Inhibition Of Lung Cancer By Grn163L: A Novel Human Telomerase Inhibitor
(Amer Assoc Cancer Research, 2005)
Differential regulation of telomerase activity in normal and tumor cells provides a rationale for the design of new classes of telomerase inhibitors. The telomerase enzyme complex presents multiple potential sites for the ...
Rational Drug Redesign to Overcome Drug Resistance in Cancer Therapy: Imatinib Moving Target
(Amer Assoc Cancer Research, 2007)
Protein kinases are central targets for drug-based cancer treatment. To avoid functional impairment, the cell develops mechanisms of drug resistance, primarily based on adaptive mutations. Redesigning a drug to target a ...
Punica Granatum Peel Extract Protects Against Ionizing Radiation-Induced Enteritis and Leukocyte Apoptosis in Rats
(Oxford Univ Press, 2009)
Apoptosis/Cytokine/Enteritis/Ileum/Irradiation/Punica granatum/Pomegranate/Radioprotective. Radiation-induced enteritis is a well-recognized sequel of therapeutic irradiation. Therefore we examined the radioprotective ...
Diarrhea In Neutropenic Patients: A Prospective Cohort Study With Emphasis On Neutropenic Enterocolitis
(Oxford Univ Press, 2007)
Background: Although diarrhea is a frequent complication in neutropenic patients, its true incidence, risk factors and clinical course have not been investigated prospectively. Patients and methods: The study was carried ...
Aromatase Inhibitors In Breast Cancer: An Overview
(Wiley, 2006)
We examined published reports on the use of aromatase inhibitors in postmenopausal patients with hormone receptor-positive breast cancer. Our data were obtained through a MEDLINE search of literature published in English. ...
Thymic Malignancy In A Breast Cancer Patient - Is There An Association With Anti-Estrogenic Effects Of Tamoxifen?
(Taylor & Francis Ltd, 2004)
Wwox And Ap2 Gamma Expression Levels Predict Tamoxifen Response
(Amer Assoc Cancer Research, 2007)
Purpose: Assessment of expression levels of Wwox, Wwox- interacting proteins Ap2 alpha, Ap2 gamma, and ErbB4, the Ap2 gamma transcriptional target protein Her2, and the possible Ap2 alpha transcriptional target Prka Rl ...
Primary Tumor Cells Obtained from Mnu-Induced Mammary Carcinomas Show Immune Heterogeneity Which Can Be Modulated by Low-Efficiency Transfection of Cd40L Gene
(Landes Bioscience, 2009)
The presence of CD40 on carcinoma cells is an important factor for the generation of tumor-specific responses induced by CD40 ligation. In an N-methyl-N-nitrosourea (MNU)-induced autochthonous mammary tumor model, we ...