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Toplam kayıt 85, listelenen: 31-40
Few Drugs Display Flip-Flop Pharmacokinetics And These Are Primarily Associated With Classes 3 And 4 Of The Bddcs
(Wiley, 2015)
This study was conducted to determine the number of drugs exhibiting flip-flop pharmacokinetics following oral (p.o.) dosing from immediate-release dosage forms and if they exhibit a common characteristic that may be ...
Long-Circulating Peg-Pe Micelles Co-Loaded with Paclitaxel and Elacridar (Gg918) Overcome Multidrug Resistance
(Taylor & Francis Ltd, 2012)
Overexpression of drug efflux pump P-gp is one of the major reasons to cause multidrug resistance (MDR). To overcome P-gp mediated MDR, modulators, so called P-gp inhibitors, can be used to block efflux pump activity. ...
Preparation and In Vitro/In Vivo Evaluation of Microparticle Formulations Containing Meloxicam
(Springer, 2012)
In this study, we have formulated chitosan-coated sodium alginate microparticles containing meloxicam (MLX) and aimed to investigate the correlation between in vitro release and in vivo absorbed percentages of meloxicam. ...
Network On Veterinary Medicines Initiated By The European Federation For Pharmaceutical Sciences
(Wiley, 2018)
The European Federation for Pharmaceutical Sciences (EUFEPS) was founded 25 years ago by more than 20 national pharmaceutical societies and faculty members. As a pan-European organization, it brings together pharmaceutical ...
5-Hydroxytryptamine Does Not Reduce Sympathetic Nerve Activity or Neuroeffector Function In The Splanchnic Circulation
(Elsevier Science Bv, 2015)
Infusion of 5-hydroxytryptamine (5 HI) in conscious rats results in a sustained (up to 30 days) fall in blood pressure. This is accompanied by an increase in splanchnic blood flow. Because the splanchnic circulation is ...
Decreased Activity And Genetic Polymorphisms Of Cyp2C19 In Behcet'S Disease
(Wiley, 2017)
Behcet's disease (BD) is a systemic autoimmune disorder. Cytochrome P450 enzymes (CYPs) are responsible for various drug metabolism reactions as well as those of endogenous substances which may be associated with autoimmune ...
Alpha(1)-Adrenoceptor-Mediated Contraction Of Rat Aorta Is Partly Mediated Via Transactivation Of The Epidermal Growth Factor Receptor
(Wiley-Blackwell, 2010)
Background and purpose: High level of plasma catecholamines is a risk factor for vascular diseases such as hypertension and atherosclerosis. Catecholamines induce hypertrophy of vascular smooth muscle through alpha(1)-ad ...
Investigating the Structural Influence of Surface Mutations on Acetylcholinesterase Inhibition by Organophosphorus Compounds and Oxime Reactivation
(Elsevier Ireland Ltd, 2010)
Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Binary mixtures of mammalian AChE and oximes of varying structure have ...
In Vitro Effects Of Rosmarinic Acid On Glutathione Reductase And Glucose 6-Phosphate Dehydrogenase
(Taylor & Francis Ltd, 2011)
Context: Glutathione reductase (GR, NADPH:oxidized glutathione oxidoreductase, E. C 1.6.4.2) is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized glutathione (GSSG). GR is a crucial enzyme in the ...
Rp-Hplc Method Development and Validation for Estimation of Rivaroxaban in Pharmaceutical Dosage Forms
(Univ Sao Paulo, Conjunto Quimicas, 2013)
Rivaroxaban, an anti-clotting medication, acts at a crucial point in the blood-clotting process and stops the formation of blood clots. In this study, RP-HPLC method was developed for the determination of rivaroxaban in ...