Yayıncı "Amer Assoc Cancer Research" için listeleme

Toplam kayıt 10, listelenen: 1-10

    • A Role for Endothelin-2 and Its Receptors in Breast Tumor Cell Invasion 

      Grimshaw, MJ; Hagemann, T; Ayhan, A; Gillett, CE; Binder, C; Balkwill, FR (Amer Assoc Cancer Research, 2004)
      We have studied the role of endothelins (ET-1, ET-2 and ET-3) and ET receptors (ET-RA and ET-RB) in the invasive capacity of breast tumor cells, which express ET-I and ET-2 as well as ET-RA and ET-RB. Of five human breast ...

    • Antiadhesive Effects of Grn163L - An Oligonucleotide N3 '-> P5 ' Thio-Phosphoramidate Targeting Telomerase 

      Jackson, Shalmica R.; Zhu, Chun-Hong; Paulson, Vera; Watkins, Linda; Dikmen, Z. Gunnur; Gryaznov, Sergei M.; Wright, Woodring L.; Shay, Jerry W. (Amer Assoc Cancer Research, 2007)
      We determined previously that a novel human telomerase RNA (hTR) antagonist, GRN163L, inhibited the tumorigenic potential of A549-luciferase (A549-luc) lung cancer cells in vitro and in vivo. Further studies revealed that ...

    • Genetic Predisposition To Fiber Carcinogenesis Causes A Mesothelioma Epidemic In Turkey 

      Dogan, A. Umran; Baris, Y. Izzettin; Dogan, Meral; Emri, Salih; Steele, Ian; Elmishad, Amira G.; Carbone, Michele (Amer Assoc Cancer Research, 2006)
      Malignant mesothelioma in the western world is often associated with asbestos exposure. It is a relatively rare cancer that causes similar to 2,500 deaths yearly in the United States and 1,000 deaths yearly in the United ...

    • In Vivo Inhibition Of Lung Cancer By Grn163L: A Novel Human Telomerase Inhibitor 

      Dikmen, ZG; Gellert, GC; Jackson, S; Gryaznov, S; Tressler, R; Dogan, P; Wright, WE; Shay, JW (Amer Assoc Cancer Research, 2005)
      Differential regulation of telomerase activity in normal and tumor cells provides a rationale for the design of new classes of telomerase inhibitors. The telomerase enzyme complex presents multiple potential sites for the ...

    • Induction Of Telomere Dysfunction Mediated By The Telomerase Substrate Precursor 6-Thio-2'-Deoxyguanosine 

      Mender, Ilgen; Gryaznov, Sergei; Dikmen, Z. Gunnur; Wright, Woodring E.; Shay, Jerry W. (Amer Assoc Cancer Research, 2015)
      The relationships between telomerase and telomeres represent attractive targets for new anticancer agents. Here, we report that the nucleoside analogue 6-thio-2'-deoxyguanosine (6-thio-dG) is recognized by telomerase and ...

    • Rational Drug Redesign to Overcome Drug Resistance in Cancer Therapy: Imatinib Moving Target 

      Fernandez, Ariel; Sanguino, Angela; Peng, Zhenghong; Crespo, Alejandro; Ozturk, Eylem; Zhang, Xi; Wang, Shimei; Bornmann, William; Lopez-Berestein, Gabriel (Amer Assoc Cancer Research, 2007)
      Protein kinases are central targets for drug-based cancer treatment. To avoid functional impairment, the cell develops mechanisms of drug resistance, primarily based on adaptive mutations. Redesigning a drug to target a ...

    • Reactivation of Camp Pathway by Pde4D Inhibition Represents A Novel Druggable Axis for Overcoming Tamoxifen Resistance in Er-Positive Breast Cancer 

      Mishra, Rasmi R.; Belder, Nevin; Ansari, Suhail A.; Kayhan, Merve; Bal, Hilal; Raza, Umar; Ersan, Pelin G.; Tokat, Unal M.; Eyupoglu, Erol; Saatci, Ozge; Jandaghi, Pouria; Wiemann, Stefan; Uner, Aysegul; Cekic, Caglar; Riazalhosseini, Yasser; Sahin, Ozgur (Amer Assoc Cancer Research, 2018)
      Purpose: Tamoxifen remains an important hormonal therapy for ER-positive breast cancer; however, development of resistance is a major obstacle in clinics. Here, we aimed to identify novel mechanisms of tamoxifen resistance ...

    • Sustained Adrenergic Signaling Promotes Intratumoral Innervation Through Bdnf Induction 

      Allen, Julie K.; Armaiz-Pena, Guillermo N.; Nagaraja, Archana S.; Özcan, Merve (Amer Assoc Cancer Research, 2018)
      Mounting clinical and preclinical evidence supports a key role for sustained adrenergic signaling in the tumor microenvironment as a driver of tumor growth and progression. However, the mechanisms by which adrenergic ...

    • The Inflammatory Cytokine Tumor Necrosis Factor-Alpha Generates An Autocrine Tumor-Promoting Network In Epithelial Ovarian Cancer Cells 

      Kulbe, Hagen; Thompson, Richard; Wilson, Julia L.; Robinson, Stephen; Hagemann, Thorsten; Fatah, Rewas; Gould, David; Ayhan, Ayse; Balkwill, Frances (Amer Assoc Cancer Research, 2007)
      Constitutive expression of the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) is characteristic of malignant ovarian surface epithelium. We investigated the hypothesis that this autocrine action of TNF-alpha ...

    • Wwox And Ap2 Gamma Expression Levels Predict Tamoxifen Response 

      Guler, Gulnur; Iliopoulos, Dimitrios; Guler, Nilufer; Himmetoglu, Cigdem; Hayran, Mutlu; Huebner, Kay (Amer Assoc Cancer Research, 2007)
      Purpose: Assessment of expression levels of Wwox, Wwox- interacting proteins Ap2 alpha, Ap2 gamma, and ErbB4, the Ap2 gamma transcriptional target protein Her2, and the possible Ap2 alpha transcriptional target Prka Rl ...