Bölüm "Biyoinformatik" için listeleme
Toplam kayıt 15, listelenen: 1-15
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Archaeogenomic Analysis of The First Steps of Neolithization in Anatolia and The Aegean
(Royal Soc, 2017)The Neolithic transition in west Eurasia occurred in two main steps: the gradual development of sedentism and plant cultivation in the Near East and the subsequent spread of Neolithic cultures into the Aegean and across ... -
Automated Design vf Drug Candidate Molecules with Deep Graph Learning
(Sağlık Bilimleri Enstitüsü, 2023)The discovery of new drug candidate molecules is an important step in the process of drug development. Deep generative learning, a frequently used approach in the field of artificial intelligence in recent years, has emerged ... -
Bayesian Networks for Omics Data Analysis in Hepatocellular Carcinoma Single-Cell Sequencing
(Sağlık Bilimleri Enstitüsü, 2021)Single cell multi omics techniques have shown an advancement in unrevealing complex diseases like cancer heterogeneity by providing multi-faceted insight into their individual cellular regulations. In this study, a machine ... -
Comparing the Melissopalynological and Next Generation Sequencing (NGS) Methods for the Determining of Botanical Origin of Honey
(2021)The aim of this study is to compare the melissopalynological method with Next-Generation Sequencing (NGS) for determining the botanical origin of honey. Fortyhoney samples were selected by considering the total number of ... -
Dört Farklı Kansere Ait Transkriptom Verisinin In Sılıco Karşılaştırılması ve Pankreas Kanserine Özgü Biyobelirteç Adaylarının Belirlenmesi
(Sağlık Bilimleri Enstitüsü, 2021-02-23)Pancreatic cancer is the 11th most common cancer worldwide. Five-year survival of lung, colon and stomach cancers, which are the top three in cancer related deaths, are 19%, 65% and 20%, respectively. Although pancreatic ... -
Frontonazal Nadir Bir Yüz Malformasyonu ile İlişkili Aday Genlerde Protein Düzeyinde In Silico Analiz
(Sağlık Bilimleri Enstitüsü, 2022)Frontonasal malformations are diseases that develop in the median facial line and appear in variable phenotypic features. A family of 5 affected and 2 unaffected individuals were studied by microarray and whole-exome ... -
Functionally Conserved Effects of Rapamycin Exposure on Zebrafish
(Spandıdos Publications, 2016)Mechanistic target of rapamycin (mTOR) is a conserved serine/threonine kinase important in cell proliferation, growth and protein translation. Rapamycin, a well‑known anti‑cancer agent and immunosuppressant drug, inhibits ... -
Heterojen Biyomedikal Verinin Bilgi Çizgeleri ve Derin Öğrenme Tabanlı Analizi ile Protein Fonksiyonlarının Otomatik Tahmini
(Sağlık Bilimleri Enstitüsü, 2023-07-31)Proteins are vital for cellular processes, and accurately determining their functions is crucial for understanding complex biological mechanisms. Computational approaches have emerged as alternatives to expensive and ... -
Image, Sequence, and Interactome Based Prediction of Subcellular Localization of Proteins
(Sağlık Bilimleri Enstitüsü, 2024-01-31)Knowledge of subcellular localization (SL) of proteins is essential for drug development, systems biology, proteomics, and functional genomics. Due to the high costs associated with experimental studies, it has become ... -
Kişiselleştirilmiş Sağkalım Tahmini İçin Geniş Çaplı Kanser Verisinin Yapay Öğrenme ve Çoklu-Omik Bazlı Analizi
(Sağlık Bilimleri Enstitüsü, 2022)Cancer is one of the leading causes of death worldwide. The high lethality of some of the sub-types of cancer increases the importance of correct diagnosis, complete follow-up and effective treatment. Survivability in ... -
Kompleks Hastalıklarla İlişkili Genetik Varyasyonun Zaman-Serisi Genom Dizileme Verilerinde Popülasyon Genetiği Yaklaşımları ile İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023-06-19)Genetic diseases are the products of evolutionary process. The demographic history of anatomically modern humans over the last 200.000 years has shaped the genetic structure associated with common diseases. It is possible ... -
Mikrodizin kaynaklı genotip bilgisi kullanılarak kopya sayısı değişikliklerinde mozaiklik oranının saptanması
(Sağlık Bilimleri Enstitüsü, 2023)Acun, H. M., Determination of Mosaicism Ratio in Copy Number Variations Using Microarray Based Genotype Information, Hacettepe University Graduate School of Health Sciences Department of Bioinformatics Master’s Thesis, ... -
Prcell: Sentetik Biyoloji için Sinyal Yolağı Programlamaya Yönelik Bir Yazılım
(Sağlık Bilimleri Enstitüsü, 2019)Synthetic biology is a new and interdisciplinary field of research aimed at applying the fundamental principles of engineering to biology, especially to the cell. It aims to design and produce artificial biological systems. ... -
Smoking Induces Coordinated Dna Methylation and Gene Expression Changes in Adipose Tissue with Consequences for Metabolic Health
(Springer Nature, 2018)Background: Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes. Many smoking-associated signals have been detected in the blood methylome, but the extent to which ... -
Yapay Öğrenme Bazlı Hesaplamalı Modelleme İle Geniş Çaplı Kanser Hücre Hattı İlaç Yanıt Tahmini
(Sağlık Bilimleri Enstitüsü, 2022)Assessing the best treatment option specifically for each patient is the main goal of precision medicine. The patients with the same diagnosis may display varying sensitivity to the applied treatment due to genetic ...